Amicus Therapeutics Quest To Cure Rare And Orphan Diseases

Amicus Therapeutics is a company in the biotechnology industry that is headquartered in Cranbury, New Jersey. It is a publicly traded company (Nasdaq: FOLD) that had its initial public offering in 2007. Prior to going public early investors in Amicus Therapeutics were New Enterprise Associates, Radius Ventures, and Canaan Partners.

It is providing cures for rare and orphan diseases that Amicus Therapeutics has as its mission. One set of disorders they are particularly focused on providing a cure for are lysosomal storage disorders. The platform that this company uses to develop products is Chaperone-Advanced Replacement Therapy (Seeking Alpha). They have a number of enzyme replacement therapies in various stages of development.

At Amicus Therapeutics they have three medical issues in particular that they are working on. These are Fabry disease, Epidermolysis Bullosa, and Pompe Disease. They have five drugs under development. The ones furthest along are for Fabry Disease. They have one drug, Galafold (Migalastat) Monotherapy that has been approved for use in the European Union. SD-101 is a topical drug being developed for Epidermolysis Bullosa that is in Stage 3 of development. For Pompe Disease the drug under development is ATB200/AT2221 which is in Phase 2.

Over the years Amicus Therapeutics has received grants in support of the diseases it is seeking to cure. Two of these occurred in 2010. the Michael J. Fox Foundation gave a $500,000 grant in that year while the Alzheimer’s Drug Discovery Foundation granted $210,300.

Amicus Therapeutics is led by Chairman of the Board and Chief Executive Officer John Crowley. He has been in the biotechnology field for almost 20 years. Another top leader of the firm is Bradley Campbell who is the President and Chief Operating Officer. Among the other senior executives are Chief Financial Officer Chip Baird and two Chief Science Officers, Hung Do Ph.D. and Jay Barth M.D.

Osteo Relief Institute Provides Solutions to Joint Pains

Although arthritis is common, many people do not understand it. It is not a single disease but one associated with joint pains. Here are over 100 different types of arthritis which afflict over 50 million Americans, most of which are women. It is common with the elderly and usually results in disability. Osteoarthritis is the most common type of arthritis. Its most common symptom is the degeneration of the cartilage, a soft tissue found between joints.



This situation causes friction between bones resulting in pain, stiffness, and swellings. This condition has no cure but can be managed through various treatment methods (YourBeautyCraze). However, the disease is associated with several risk factors which include family history, excessive weight, or previous injury. Since the disease is incurable, it should be managed to reduce its scope and speed of development. Some of these management practices include


  • Engaging in daily routine



  • Exercises



  • Medical options



The Osteo Relief Institute, which is based New Jersey, is an independently owned organization that offers patient care and communication. Apart from having state of the art equipment, Osteo relief Institute have also a highly trained staff able to provide satisfying pain relief solutions to patients. Their equipment is FDA-approved and fully cleared for use.



The primary objective of Osteo relief Institute is to help patients avoid surgery by providing effective treatment methods with little or no downtime. They have multidisciplinary clinics which are made up of a team of board-certified physical therapists and physicians. This group of professionals treat patients as a family and cater for their varying health conditions.



Each location of Osteo relief Institute is owned independently and is specialized in offering patient-centered care and communication. Explanations regarding the different types of treatments are done in plain and simple English to help patients make educated decisions regarding their health conditions.



The Osteo Relief Institute has advanced regarding its treatment approaches which help patients to avoid disability. They can handle each medical case depending on its stage of development and severity. The institute tries as much as possible to reduce the physical pain and anguish experienced by the patient by the application of noninvasive treatment approaches.

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Eli Gershkovitch Craft Beer Genius and Creator of Steamworks

Eli Gershkovitch of Steamworks is aware of his competitors in Ontario Canada and their growing fame as successful craft breweries. In fact in the recent U.S. Open Beer Championship, one Ontario brewery ranked among the top 10 beer breweries. Kitchener, Ontario is the home of the Brick Brewing Company, Limited and the Waterloo Brewing Company. Oakville, Ontario is the base for Cameron’s Brewing and the All or Nothing Brewhouse. Ontario also has breweries in Barrie and Oakland, the Flying Monkey Craft Brewery and the Nickel Brook Brewery Co.


The Breweries have their specialties, such as Brick produces Laker Lager; All Or Nothing has three styles it promotes, Hopfenweisse, Peach Braggot and Masala Chai Braggot; Cameron produces five beers including Ambear Red Ale and Rye Pale Ale; Flying Monkey has twelve top seller, including the Manifesto Triple Chocolate Stout; Nickel Brook sells Headstock India Pale Ale (IPA); Waterloo offers six beers, including Grapefruit Adler.


That’s just one area of the great country of Canada. Eli Gershkovitch Steamworks Brewery is in Vancouver, British Columbia. A great craft beer company, Steamworks was founded by Eli Gershkovitch in 1995. He began his venture into brewing as a pub owner (WingsJournal). Recalling his experiences during a European trip, he decided to try his hand at craft beer. Today, Steamworks produces thirteen varieties of craft beer, three of which are well known: Pumpkin Ale, Flagship IPA and Tall Can Mash Up.


The greatest proof that Canadian craft beer is very popular among consumers is in the sales, but it is also reflected in its acceptance among its competitors. In the 2017 U.S. Open Beer Championship, Canadian beers won 24 awards and 10 gold medals. Eli Gershkovitch and other Canadian brew masters competed against other breweries from all over the world. Steamworks is now sold all over Canada and in fourteen states in the U.S. For two years in a row, Steamworks led by Eli Gershkovitch has been awarded the title of Best BC Craft Beer by BC Craft Beer Awards. In 2013, Steamworks Pumpkin Ale received a gold medal at the Canadian Brewing Awards.


Steamworks along with its Canadian brew master competitors are creating the newest taste in craft beer. Canada and Eli Gershkovitch’s Steamworks are constantly developing tasty new lagers, pilsners, and ales that are steadily putting North America ahead of the world’s craft beer brewmasters.

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Dr. Avi Weisfogel: A Sleep Expert

Dr. Avi Weisfogel is a specialist in treating sleep apnea using dentistry. He is based in New Jersey and has been practicing for over twenty years. Sleep apnea is a sleep condition highlighted by unexpected breathing breaks that hinder a smooth sleeping pattern. The condition is common among overweight individuals.

Education and Career Path of Dr. Avi Weisfogel

Dr. Weisfogel studied a Bachelor’s Degree in Biology and Psychology at the University of Rutgers. He later proceeded to the University of New York to study a Ph.D. in Dental Surgery. Equipped with this these skills, Dr. Weisfogel started a private practice named Old Bridge Dental Care. His relentless efforts in serving people led to his practice receiving awards in two consecutive years.

Strategies applied by Dr. Weisfogel in his dental practice that led to the success of his career were well thought out and executed. In the year 2012, he formed Unlimited Sleep Patients. This gave many experts an avenue for pooling information on sleep apnea. He utilized this opportunity to lecture people on sleep dentistry. By launching the Dental Sleep Master’s Program, he was able to compile tailor-made equipment for treating sleep apnea. In 2010, he pioneered the Healthy Heart Sleep also for information sharing with other physicians. He taught professions how to initial and manage sleep laboratories.

Being a very innovative man, Dr. Weisfogel established the Dental Sleep Masters in the year 2014 to analyze and manage complications related to obstructive sleep apnea and dentistry. He spent close to ten years marketing his enterprise and educating other professionals in the medical field. Avi used his background in marketing to reach out to people through billboards, online marketing, television advertisements and newspaper articles. His thriving business came as a result of hard work and excellent public relations that gave him valuable referrals.

Aside from touching people’s lives as a doctor, Dr. Avi Weisfogel is a well-known philanthropist in charitable organizations. He has a passion for reading inspiring books and has authored the book, “The Power of Now.” He loves playing tennis and basketball.

Dr. Weisfogel advises people never to give up on their dreams and to get mentors to guide them in their career journey.

Healthy, Sustainable, and Delicious: Waiakea Water

Bottled water has been known to cause pollution since the plastic bottles increase wastes in the environment. For many years, companies have always thought that the solution is to make the bottles stronger and degradable. Unfortunately, the plastics they use are compostable and not degradable. Waiakea Water has finally found the perfect solution for water bottles.

The First 100% Degradable Plastic Bottle in the World

Waiakea decided to do the opposite by using Timeplast nano-degradable additive, which makes the plastic weak rather than strong. The additive reduces the lifespan of the plastic, making it degradable after a short period. Waiakea will also chip in and chemically degrade it’s plastic, which is purely made from recycled bottles. They also convert the plastic into wax, which is fully biodegradable. The company will start using this world’s only fully degradable plastic next year.

Waiakea Volcanic Water Brand

Waiakea is a bottled water company that was started in 2012 by its founder, Ryan Emmons. Ryan discovered a sustainable water source in Hawaii Island whose water is rich in silica, sodium, magnesium, and potassium with an alkaline pH. The water is naturally generated using the power produced by volcanos. It goes over high volcanic rock collecting minerals along the way.

The Hawaii company is not only environmentally-conscious, but also known for its charity work. It takes the initiative to donate millions of liters of water to areas experiencing shortage. It distributes its water in Hawaii, throughout the US, and the outside countries too.

Being the fastest growing bottled water company in the US at a rate of 4200% in three years, it is evident that the company is fulfilling its mission of providing healthy, sustainable water to consumers and donating some to those in need.

The value of bottled water is not only in the taste, but also the contents, its source, the packaging and its effect on the environment.

Dr. Mark Holterman, Medical Visionary

Dr. Mark Holterman has blogged and written extensively about subjects such as the topic of Bariatric Surgery. The purpose of Bariatric surgery is to reduce the stomach’s ability to absorb food. By the means of a Gastric Bypass, the overall size of the patient’s stomach is reduced. With a sleeve Gastrectomy, surgeons remove a large portion of the stomach, which dramatically reduces the size of the stomach, keeping the patient from overeating. The Gastric Band procedure places a band around the stomach, which limits its’ diameter.


One of Dr. Mark Holterman’s main professional interests lies in stem cell therapy, as he is a co-founder of the Alliance for the Advancement of Cellular Therapies. (AACT)

Cellular therapy is the process by which healthy cells are transplanted in order to replace damaged cells and tissue. Transplanting cells can replace damaged cells or simply enhance the healing process. The most widely used version of the therapy is HSC, or hematopoietic stem cells, which is most effective in patients that have certain types of blood cancers (WeeklyOpinion). It’s the hope of many physicians that cellular therapy will eventually be used to treat a variety of other conditions including autoimmune disorders and tendinitis.


Dr. Mark Holterman has worked at the University of Illinois College of Medicine since 2011, as a professor ( He also works at the Advocate Christ Medical Center and the St. Francis Medical Center as a Pediatric Surgeon. An accomplished man, he holds several memberships with other professional organizations as well, such as the American College of Surgeons and the American Academy of Pediatrics.


Though Dr. Mark Holterman specializes in pediatric surgery, his research interests span a variety of topics including regenerative medicines, obesity, and novel cancer treatments, as well as stem cell therapies. Dr. Mark Holterman attended Yale, where his major was biology. He managed to do well, graduating cum laude after which, he earned his Ph.D. and MD from the University of Virginia.


How Louis Chenevert Transformed the Aviation Industry

Louis Chenevert resilience to success is unimaginably impressive. He is an industrious individual who earns an incredible reputation in the corporate world. Mr. Louis prides himself on spearheading the growth and development of United Technologies Corporation during his tenure at the firm. He was born and raised in France before relocating to Canada. Louis Chenevert pursued his passion in production management at the University of Montreal. He used his academic credentials to secure several job opportunities in the business world.

The French-Canadian held several positions as a director and a board member of various institutions including Business Roundtable, Yale Cancer Center’s Advisory Board, American Institute of Aeronautics and Astronautics, Cargill and Congressional Medal of Honor Foundation. Louis Chenevert currently provides advisory services to organizations in Canada. He is the current sole advisor of Merchant Banking Solutions of Goldman Sachs since his appointment in 2014. Over the years, Mr. Louis gained leadership skills from the top management positions that he served in various companies.

Louis Chenevert’s academic qualifications earned him his first job opportunity at General Motors. He was appointed to head the entire division of the firm that was located in St. Therese. The French-Canadian served the production unit as the general manager for 14 years before his resignation in 1993. His knowledge and skills in the manufacturing industry attracted United Technologies Corporation. Mr. Louis held several positions during his tenure at Pratt and Whitney, which was a branch of UTC. He became the president of UTC after serving Pratt and Whitney for over six years. Louis Chenevert was also privileged to help the firm as the chief executive officer since 2006 to 2014 before his resignation.

During his tenure as the CEO of UTC, Louis Chenevert set a legacy that earns him an incredible reputation in the firm. Employees of the company recognize him for his efforts in incorporating technology into the company and scholarship programs that he initiated. Mr. Louis played a vital role in the acquisition of Goodrich. The company expanded its business to become the primary supplier of the F-35 engines, the geared turbofan engines, and the GTF engines. His stewardship spearheaded the firm to be the largest manufacturer of helicopters in the US.

How Stream Energy Company Managed to Take Over the Energy Industry.

It comes as a surprise to many when they get unexpectedly hefty electricity bills. It could be so exasperating for many especially if you went to lengths to try and lessen the energy bill yet eventually it bears no fruit.

One of the reasons you might be getting a high electricity bill than you expect at home or your office could be because your appliances use up electricity even when you switch them off. Despite the fact that they might not be in active use most of the time, they still consume a significant amount of energy. As much as it might be insignificant, over time, it is compounded and thus changes your overall consumption.


For example; unplugging your coffee maker from the socket after use can save you about a dollar a year. It is the same for other appliances like sandwich toasters, laundry machine, and even your computers monitor. The outcome gets even worse when you decide and cut power supply to your DVR each time you are not using it (DallasNews). For your entire entertainment system, you could save up to$13 per year. Put together this amount could be more and therefore you can be able to spend it on something even more fulfilling.


All one needs to get their money back is consciousness. If you can’t be diligent, you’ll continue paying handsomely for your electricity bill. By sorting out your gadgets in the house or office and putting them on power strips or even switching off the primary source of power when they are not in use can help you save and set aside money for other activities. It’s a possible way of ensuring your hard earned money does not disappear.

Stream Energy, a company in the energy sector that provides solutions for homes and offices was founded in the year 2005.


Since then it has continuously managed to surpass its inaugural expectation by becoming a force to reckon in the energy industry ( Just by selling directly to people and by word of mouth, the company has improved its product offering and increased clientele.


Jorge Moll: Bring Quality Healthcare Closer to the Brazilian Public

Over the course of the last few decades, Brazil has experienced tremendous economic growth. This has been accompanied by tens of millions of its citizens joining the formal sector. With many having more disposable income, the demand for quality products and services, including healthcare, has gone up. Consequently, in the last few decades, many Brazilians have stopped using the often crowded public hospitals and have instead started using emerging networks of private hospitals. One of the hospital networks that has been at the center of this migration is Rede D’Or. Now the largest independent hospital network in the country, it was co-founded by respected cardiologist and entrepreneur, Jorge Moll (

Jorge Moll co-founded D’Or in 1977 as a diagnostic imaging laboratory. With time, however, he expanded the humble business into a collection of hospitals and laboratories. Today, there are more than 30 hospitals under the D’Or brand. In 2010, the company decided to sell its subsidiary laboratories for about three-quarters of a billion dollars while at the same time acquiring another hospital group, Sao Luiz.

Perhaps the greatest reason for D’Or’s success is Jorge Moll’s insistence on adhering to international standards (Scholar.Google). Early on when starting out, he modeled his first hospital around one Mayo clinic in Minnesota, USA. Consequently, his hospitals often featured services that were lacking in other hospitals, thus adding to their overall appeal. He made sure to keep the emergency department open to all, even those who did not have insurance.

Going forward, Jorge Moll has made it no secret that he intends to expand D’Or even further, but it is expected that this endeavor will not be met without a few challenges. While the company primarily operates in Sao Paulo and Rio de Janeiro, plans are underway to expand into other areas of the country including the cities of Brasilia and Copacabana. As with any other huge organization, D’Or will likely face challenges associated with gigantism, particular slow growth. Additionally, with international brands getting into the country, D’Or will likely face additional competition. What is more, many of the company’s local competitors also have ambitious expansion plans.

More about Jorge Moll on Wikipedia

Unsung Hero, James Larkin

Not all heros in history are well known in the general population. These are unsung heros who are more into the passion of the cause than being in a social studies book. An example of this type of man is James Larkin.

Born in 1874, he was a hero in his own time and social circles. His work has paved the way for everyone who works today.

An Irish Hero

If you have not heard of the man who organized the Irish Transport and General Workers’ Union, you are about to. James Larkin was an Irish labor organizer and activist who founded the.

He believed seriously in Karl Marx’s ideas known as Marxism, meaning that society changes depending on economic factors of production.

Early Life

Not always a famous folk hero, James Larkin had a rough start in the sound of his hometown of Liverpool. His family was extremely poor and he was forced to work early to keep the family going.

Jim Larkin worked many odd jobs as a young boy until his big break as a foreman down at the docks of Liverpool.

This is where is socialist fire was ignited and he joined the National Union of Dock Laborers where he was extremely successful! He acquired a position S a trade organiser by 1905.

Too Much For This Union

He believed in militant strikes and was moved to Dublin 2 years later. This is where he created the union which united all industrial workers. It didn’t matter If you were an expert in your trade or a new apprentice.

All were welcome. Afterwards he created the Irish labor party that had numerous lockouts for long periods of time. He helped all Irish workers gain fair wages.

Learn more about Jim Larkin: